Similarly, a strong association between coffee consumption and mortality from coronary heart disease, reported after 6 years of follow-up,5 was weakened by 6 more years of follow-up.6 The decreased effect of coffee after longer follow-up could also be a result of caffeine having a weaker effect in an older population. To determine whether CYP1A2 genotype modifies the association between coffee consumption and risk of acute nonfatal MI. A2 adenosine receptors, located in coronary endothelial and smooth muscle cells, are responsible for stimulation of this enzyme activity. It is expected that dietitians will be key players in this area. Conclusions: Gu L, Gonzalez FJ, Kalow W, Tang BK. Coffee and coronary heart disease. with hypertension and myocardial infarction (MI) are different between slow and rapid metabolizers as defined by CYP1A2 genotype with adjustment for confounding factors. Additionally, after the 24-week diet and 18-month follow up the low-GI nutrigenetic diet group had significantly greater (p < 0.0001) improvements in total cholesterol (ketogenic - 35.4 ± 32.2 mg/dl; low-GI nutrigenetic - 52.5 ± 24.3 mg/dl), HDL cholesterol (ketogenic + 4.7 ± 4.5 mg/dl; low-GI nutrigenetic + 11.9 ± 4.1 mg/dl), and fasting glucose (ketogenic - 13.7 ± 8.4 mg/dl; low-GI nutrigenetic - 24.7 ± 7.4 mg/dl). Of the participants, 60.5% were women and 39.5% were men. Hamdy SI, Hiratsuka M, Narahara K.